Bloom Krans Full Bloom Hair Rejuvenating Fusion Blend

There are many hair loss products on the market, but even more hype surrounding whether those products work. To make it simpler for you, we have picked popular hair loss products and explained their ingredients, one by one. Is there any clinical evidence for them working, or is it based on unreliable anecdotal recounts of success? 

This weeks product to be reviewed is the Bloom Krans Full Bloom Hair Rejuvenating Fusion Blend dietary supplement. 

Ingredients

The product contains the ingredients

• Procyanidin B2
• Bamboo extract
• Grape seed extracts
• Saw palmetto
• Vitamins A, C, D, B1, B2, B3, B7, B9, B12 and H (also called biotin)

Scientific or Clinical evidence

Ingredient	Introduction	Clinical evidence	Verdict
Procyanidin B2	Natural product that can be extracted from apples	Applying directly to head showed increased hair growth and hair diameter in men (1) Alters hair growth factors in mouse hair cells (2)	Evidence for topical application Evidence as a dietary supplement not very conclusive
Bamboo extract	Extract from bamboo contains silica which is proposed to aid hair growth	Silica exists in hair so hair will suffer if there is a deficiency	Useful in the case of a silica deficiency. Silica obtained from a natural extract, so present in relatively low quantities that is at low risk of side effects.
Grape seed extract	Extract from grape seeds contains proanthocyanidins and antioxidants that is proposed to aid hair growth	Grape seed proanthocyanidins promote hair follicle cell growth in mouse (3, 4) Antioxidant activity of grape seed extract has been shown (5) High lipid peroxidation (“free radicals”) in scalp of some hair loss patients (6)	Limited evidence that it works when applied topically No evidence that antioxidant activity of grape seed extract exceeds other antioxidants for hair loss
Saw palmetto	Palm leaves that contain active ingredients liposterolic acid and β-sitosterol	Some evidence that fatty acids can inhibit 5ARI, which is implicated in hair loss (7) One small trial in 1999 involving 6 out of 10 men taking saw palmetto had better hair (8) [random, double blind, placebo-controlled trial]	Some evidence suggested that saw palmetto may be able to aid hair loss, but not conclusive. The only scientific trial involving humans was done in a somewhat scientifically rigorous manner, but didn't assess follicular diameter or density.
Vitamin C	Vitamin C has antioxidant effects	Higher than normal levels of free radicals in the scalp of certain hair loss patients (6) Hair loss observed in scurvy patients (condition resulting from vitamin C deficiency) (9)	Evidence that vitamin C supplementation may prevent hair loss in the case of vitamin C deficiency. If one doesn't have a deficiency, vitamin C may not help.
Biotin	It is also known as vitamin H. It is an essential cofactor to allow certain enzymes in the body to function	Biotin deficiency reported to cause hair loss, shown in animals and in humans (although human evidence is more limited) (10, 11, 12, 13)	Evidence for biotin supplementation preventing hair loss. If one doesn't have a deficiency, biotin may not help

Final Verdict

As with many health supplements targeted to certain conditions, many are just cocktails of different individual supplements. In the case of Bloom Krans Full Bloom Hair Rejuvenating Fusion Blend, some of the supplements have some scientific evidence supporting it. These include saw palmetto, vitamin C and biotin. Some supplements have quite strong scientific evidence supporting it, such as procyanidin B2 supplement. However, the evidence for procyanidin B2 applies only when the extracted compound is applied directly to the scalp and when taken orally.

As a result, we don't recommend this product. It would be better to purchase individual products such extracted procyanidin B2, and apply it directly to the scalp as hair loss treatment.

 References

1.

Kamimura, A., Takahashi, T. & Watanabe, Y. Investigation of topical application of procyanidin B-2 from apple to identify its potential use as a hair growing agent. Phytomedicine 7, 529–536 (2000). [link]

2.

Kamimura, A. & Takahashi, T. Procyanidin B-2, extracted from apples, promotes hair growth: a laboratory study. British Journal of Dermatology 146, 41–51 (2002). [link]

3.

Takahashi, T., Kamiya, T. & Yokoo, Y. Proanthocyanidins from grape seeds promote proliferation of mouse hair follicle cells in vitro and convert hair cycle in vivo. ACTA DERMATOVENEREOLOGICA-STOCKHOLM- 78, 428–432 (1998). [link]

4.

Takahashi, T., Kamiya, T., Hasegawa, A. & Yokoo, Y. Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo. 112, 310–316 (1999). [link]

5.

Jayaprakasha, G. K., Singh, R. P. & Sakariah, K. K. Antioxidant activity of grape seed (Vitis vinifera) extracts on peroxidation models in vitro. Food chemistry 73, 285–290 (2001).

6.

Akar, A. et al. Antioxidant enzymes and lipid peroxidation in the scalp of patients with alopecia areata. Journal of dermatological science 29, 85–90 (2002).

7.

Liang, T. & Liao, S. Inhibition of steroid 5 alpha-reductase by specific aliphatic unsaturated fatty acids. Biochem. J 285, 557–562 (1992).

8.

Farris, P. K. Cosmeceuticals and cosmetic practice. (John Wiley & Sons, 2013).

9.

Stewart, C. P. & Guthrie, D. Lind’s Treatise on Scurvy. A Bicentenary Volume Containing a Reprint of the First Edition of ‘A Treatise of the Scurvy’ by James Lind. (Edinburgh: Edinburgh University Press, 1953).

10.

Baugh, C. M., Malone, J. H. & Butterworth, C. E. Human Biotin Deficiency A Case History of Biotin Deficiency Induced by Raw Egg Consumption in a Cirrhotic Patient. The American journal of clinical nutrition 21, 173–182 (1968).

11.

Nisenson, A. Seborrheic dermatitis of infants: treatment with biotin injections for the nursing mother. Pediatrics 44, 1014–1016 (1969).

12.

Riella, M. C., Broviac, J. W., Wells, M. & Scribner, B. H. Essential fatty acid deficiency in human adults during total parenteral nutrition. Annals of internal medicine 83, 786–789 (1975).

13.

Holman, R. T. Essential fatty acid deficiency. Progress in the chemistry of fats and other lipids 9, 275–348 (1971).